Dataset Information
Quantitative phosphoprotoemic analysis of cold induced signaling in jurkat cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): T Cell, Cell Culture
SUBMITTER: 
QINQIN JI
LAB HEAD: Arthur Salomon
PROVIDER: PXD001105 | Pride | 2022-02-28
REPOSITORIES: Pride
Publications
Wide-scale quantitative phosphoproteomic analysis reveals that cold treatment of T cells closely mimics soluble antibody stimulation.
Journal of proteome research 20150403 5
The activation of T lymphocytes through antigen-mediated T cell receptor (TCR) clustering is vital in regulating the adaptive immune response. Although T cell receptor signaling has been extensively studied, the fundamental mechanisms for signal initiation are not fully understood. Reduced temperatures have initiated some of the hallmarks of TCR signaling, such as increased phosphorylation and activation on ERK and calcium release from the endoplasmic reticulum, as well as coalesced the T cell m ...[more]
