Dataset Information

The role of PRDX1 in chemoresistance

ABSTRACT: The role of peroxiredoxin 1 in confering chemoresistance in glioma was analysed in a cell culture system. Cells with a lower level of peroxiredoxin 1 showed a higher level of reacitve oxigen species upon treatment with BCNU. In line with this, in a 2D DIGE based redox proteomics approach, proteins were identified showing (1) differences in their thiol state upon knockdown of PRDX1 and (2) proteins showing differences in reduded and unreduced samples.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Glioblastoma

SUBMITTER: Gereon Poschmann

LAB HEAD: Gereon Poschmann

PROVIDER: PXD001110 | Pride | 2014-12-12

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	0321.dat-pride-filtered.pride.mgf.gz	Mgf
	0321.dat-pride-filtered.pride.mztab.gz	Mztab
	0321.dat-pride-filtered.xml.gz	Xml
	0321.yep	Other
	0397.dat-pride-filtered.pride.mgf.gz	Mgf

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Publications

Redox proteomics reveal stress responsive proteins linking peroxiredoxin-1 status in glioma to chemosensitivity and oxidative stress.

Poschmann Gereon G Grzendowski Michael M Stefanski Anja A Bruns Eva E Meyer Helmut Erich HE Stühler Kai K

Biochimica et biophysica acta 20141204 6

The combined deletion of chromosomal arms 1p and 19q has been described as a prognostic marker for oligodendroglial tumors. These tumors show a better response to chemotherapy and radiotherapy. Recently, we found a lower abundance of peroxiredoxin 1 (PRDX1) in oligodendroglial tumors with 1p/19q deletion, suggesting a potential role of this enzyme in the clearance of therapy induced reactive oxygen species (ROS). Here, we confirmed the importance of PRDX1 in tumor cell survival by PRDX1 knockdow ...[more]

PMID: 25484280

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