Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA281741GSE68087
INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive
ORGANISM(S): Danio Rerio (zebrafish) (brachydanio Rerio)
TISSUE(S): Whole Body
SUBMITTER: A.H. Smits
LAB HEAD: Michiel Vermeulen
PROVIDER: PXD001164 | Pride | 2016-01-27
REPOSITORIES: Pride
Bogdanović Ozren O Smits Arne H AH de la Calle Mustienes Elisa E Tena Juan J JJ Ford Ethan E Williams Ruth R Senanayake Upeka U Schultz Matthew D MD Hontelez Saartje S van Kruijsbergen Ila I Rayon Teresa T Gnerlich Felix F Carell Thomas T Veenstra Gert Jan C GJ Manzanares Miguel M Sauka-Spengler Tatjana T Ecker Joseph R JR Vermeulen Michiel M Gómez-Skarmeta José Luis JL Lister Ryan R
Nature genetics 20160229 4
The vertebrate body plan and organs are shaped during a conserved embryonic phase called the phylotypic stage. However, the mechanisms that guide the epigenome through this transition and their evolutionary conservation remain elusive. Here we report widespread DNA demethylation of enhancers during the phylotypic period in zebrafish, Xenopus tropicalis and mouse. These enhancers are linked to developmental genes that display coordinated transcriptional and epigenomic changes in the diverse verte ...[more]