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AML_profiling - Integrated analysis of proteome, phosphotyrosine-proteome, tyrosine-kinome and tyrosine-phosphatome in acute myeloid leukemia

ABSTRACT: LC-MS/MS was used to profile total phosphotyrosine phosphatase in acute myeloid leukemia (AML) in order to find potential biomarkers, drug targets, signatures for AML classification, and its relationship with total phosphotyrosine amount in the samples.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Blood

DISEASE(S): Acute Leukemia

SUBMITTER: Jiefei Tong

LAB HEAD: Mike Moran

PROVIDER: PXD001170 | Pride | 2017-02-16

REPOSITORIES: Pride

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Integrated analysis of proteome, phosphotyrosine-proteome, tyrosine-kinome, and tyrosine-phosphatome in acute myeloid leukemia.

Tong Jiefei J Helmy Mohamed M Cavalli Florence M G FM Jin Lily L St-Germain Jonathan J Karisch Robert R Taylor Paul P Minden Mark D MD Taylor Michael D MD Neel Benjamin G BG Bader Gary D GD Moran Michael F MF

Proteomics 20170301 6

Reversible protein-tyrosine phosphorylation is catalyzed by the antagonistic actions of protein-tyrosine kinases (PTKs) and phosphatases (PTPs), and represents a major form of cell regulation. Acute myeloid leukemia (AML) is an aggressive hematological malignancy that results from the acquisition of multiple genetic alterations, which in some instances are associated with deregulated protein-phosphotyrosine (pY) mediated signaling networks. However, although individual PTKs and PTPs have been li ...[more]

PMID: 28176486

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