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Metabolic changes in adaptation to biofilm growth by streptococcus pneumoniae

ABSTRACT: Comparative analyses of protein expression between log-phase planktonic and 1-day and 7-day biofilm cultures from Streptococcus pneumoniae representing nascent and late phase biofilm growth were performed using the proteomic approach iTRAQ

INSTRUMENT(S): Q-Tof ultima

ORGANISM(S): Streptococcus Pneumoniae Sp14-bs69

SUBMITTER: Paul Skipp

LAB HEAD: Dr Paul Skipp

PROVIDER: PXD001182 | Pride | 2014-09-10

REPOSITORIES: Pride

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Pronounced metabolic changes in adaptation to biofilm growth by Streptococcus pneumoniae.

Allan Raymond N RN Skipp Paul P Jefferies Johanna J Clarke Stuart C SC Faust Saul N SN Hall-Stoodley Luanne L Webb Jeremy J

PloS one 20140904 9

Streptococcus pneumoniae accounts for a significant global burden of morbidity and mortality and biofilm development is increasingly recognised as important for colonization and infection. Analysis of protein expression patterns during biofilm development may therefore provide valuable insights to the understanding of pneumococcal persistence strategies and to improve vaccines. iTRAQ (isobaric tagging for relative and absolute quantification), a high-throughput gel-free proteomic approach which ...[more]

PMID: 25188255

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