Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Endothelial Cell Of Umbilical Vein
SUBMITTER: Sara Zanivan
LAB HEAD: Sara Zanivan
PROVIDER: PXD001186 | Pride | 2015-01-28
REPOSITORIES: Pride
Patella Francesca F Schug Zachary T ZT Persi Erez E Neilson Lisa J LJ Erami Zahra Z Avanzato Daniele D Maione Federica F Hernandez-Fernaud Juan R JR Mackay Gillian G Zheng Liang L Reid Steven S Frezza Christian C Giraudo Enrico E Fiorio Pla Alessandra A Anderson Kurt K Ruppin Eytan E Gottlieb Eyal E Zanivan Sara S
Molecular & cellular proteomics : MCP 20150108 3
Endothelial cells (ECs) play a key role to maintain the functionality of blood vessels. Altered EC permeability causes severe impairment in vessel stability and is a hallmark of pathologies such as cancer and thrombosis. Integrating label-free quantitative proteomics data into genome-wide metabolic modeling, we built up a model that predicts the metabolic fluxes in ECs when cultured on a tridimensional matrix and organize into a vascular-like network. We discovered how fatty acid oxidation incre ...[more]