Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA255236GSE59394PRJNA255235PRJNA255234
INSTRUMENT(S): LTQ
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Embryonic Stem Cell
SUBMITTER: Gareth Palidwor
LAB HEAD: Dr. William Stanford
PROVIDER: PXD001191 | Pride | 2018-10-19
REPOSITORIES: Pride
EMBO reports 20150811 10
In embryonic stem cells (ESCs), gene regulatory networks (GRNs) coordinate gene expression to maintain ESC identity; however, the complete repertoire of factors regulating the ESC state is not fully understood. Our previous temporal microarray analysis of ESC commitment identified the E3 ubiquitin ligase protein Makorin-1 (MKRN1) as a potential novel component of the ESC GRN. Here, using multilayered systems-level analyses, we compiled a MKRN1-centered interactome in undifferentiated ESCs at the ...[more]