Proteomics

Dataset Information

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Preterm birth CVF proteomics discovery


ABSTRACT: Preterm birth, defined as birth <37 weeks of gestation, is a leading cause of infant morbidity and mortality. In the United States, approximately 12% of all births are preterm.1 Despite decades of research, there has been little progress in developing effective interventions to prevent preterm birth. In fact, the rate of preterm birth has increased slightly over the last several decades.2 The ultimate goal of the Genomic and Proteomic Network for Preterm Birth Research (GPN-PBR) is to identify possible biomarkers that could predict the susceptibility to spontaneous preterm birth (SPTB) as well as to shed light on the molecular mechanisms involved in its etiologies. Understanding those mechanisms will help us predict SPTB and may facilitate the introduction of more effective prevention and treatment strategies.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

DISEASE(S): Disease Free

SUBMITTER: Suhong Zhang  

LAB HEAD: Ian A Blair

PROVIDER: PXD001268 | Pride | 2014-08-28

REPOSITORIES: Pride

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Publications

Maternal serum serpin B7 is associated with early spontaneous preterm birth.

Parry Samuel S   Zhang Heping H   Biggio Joseph J   Bukowski Radek R   Varner Michael M   Xu Yaji Y   Andrews William W WW   Saade George R GR   Esplin M Sean MS   Leite Rita R   Ilekis John J   Reddy Uma M UM   Sadovsky Yoel Y   Blair Ian A IA  

American journal of obstetrics and gynecology 20140619 6


<h4>Objective</h4>We sought to identify serum biomarkers of early spontaneous preterm birth (SPTB) using semiquantitative proteomic analyses.<h4>Study design</h4>This was a nested case-control study of pregnant women with previous SPTB. Maternal serum was collected at 19-24 and 28-32 weeks' gestation, and analyzed by liquid chromatography-multiple reaction monitoring/mass spectrometry. Targeted and shotgun proteomics identified 31 candidate proteins that were differentially expressed in pooled s  ...[more]

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