Proteomics

Dataset Information

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Comparison of ribosomes between control and dyskerin-depleted human cells


ABSTRACT: Dyskerin is a pseudouridine synthase involved in fundamental cellular processes (including rRNA and snRNA modification and telomere stabilization), whose function is altered in X-linked dyskeratosis congenita and cancer. Dyskerin role in ribosome processing was suggested to underlie the alterations in mRNA translation described in cells lacking dyskerin function. We compared the protein contents of 5 replicates of ribosomal preparations from control or dyskerin-depleted human cells.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Mammary Gland Tumor Cell Line

SUBMITTER: Yohann Couté  

LAB HEAD: Christophe Bruley

PROVIDER: PXD001274 | Pride | 2015-05-07

REPOSITORIES: Pride

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Publications

Human ribosomes from cells with reduced dyskerin levels are intrinsically altered in translation.

Penzo Marianna M   Rocchi Laura L   Brugiere Sabine S   Carnicelli Domenica D   Onofrillo Carmine C   Onofrillo Carmine C   Couté Yohann Y   Brigotti Maurizio M   Montanaro Lorenzo L  

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20150501 8


Dyskerin is a pseudouridine (ψ) synthase involved in fundamental cellular processes including uridine modification in rRNA and small nuclear RNA and telomere stabilization. Dyskerin functions are altered in X-linked dyskeratosis congenita (X-DC) and cancer. Dyskerin's role in rRNA pseudouridylation has been suggested to underlie the alterations in mRNA translation described in cells lacking dyskerin function, although relevant direct evidences are currently lacking. Our purpose was to establish  ...[more]

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