Yeast phosphoproteome - Glucose intake hampers PKA-regulated HSP90 chaperone activity
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
TISSUE(S): Cell Culture
SUBMITTER: 
Chia-Feng Tsai
LAB HEAD: Chia-Feng Tsai
PROVIDER: PXD001368 | Pride | 2019-03-18
REPOSITORIES: Pride
Publications
Glucose intake hampers PKA-regulated HSP90 chaperone activity.
Chen Yu-Chen YC Jiang Pei-Heng PH Chen Hsuan-Ming HM Chen Chang-Han CH Wang Yi-Ting YT Chen Yu-Ju YJ Yu Chia-Jung CJ Teng Shu-Chun SC
eLife 20181205
Aging is an intricate phenomenon associated with the gradual loss of physiological functions, and both nutrient sensing and proteostasis control lifespan. Although multiple approaches have facilitated the identification of candidate genes that govern longevity, the molecular mechanisms that link aging pathways are still elusive. Here, we conducted a quantitative mass spectrometry screen and identified all phosphorylation/dephosphorylation sites on yeast proteins that significantly responded to c ...[more]
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