Proteomics

Dataset Information

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Project Grandiose, cell surface protein capture

ABSTRACT: The aim of Project Grandiose has been to examine the process of somatic cell (specifically, murine fibroblast) conversion to induced pluripotent stem cells, at many levels (proteome, mRNA, DNA methylation, etc.), over the time course of the conversion. This dataset represents the cell surface proteome portion of the project, namely the set of cell surface glycoproteins that were detected over theproject time course.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Early Embryonic Cell, Skin

DISEASE(S): Disease Free

SUBMITTER: Carl White  

LAB HEAD: Peter W Zandstra

PROVIDER: PXD001456 | Pride | 2014-11-27

REPOSITORIES: Pride

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Publications

Somatic cell reprogramming to a pluripotent state continues to challenge many of our assumptions about cellular specification, and despite major efforts, we lack a complete molecular characterization of the reprograming process. To address this gap in knowledge, we generated extensive transcriptomic, epigenomic and proteomic data sets describing the reprogramming routes leading from mouse embryonic fibroblasts to induced pluripotency. Through integrative analysis, we reveal that cells transition  ...[more]