Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive
ORGANISM(S): Homo Sapiens (human) Caenorhabditis Elegans
SUBMITTER: Alba Cristobal
LAB HEAD: Albert J.R. Heck
PROVIDER: PXD001501 | Pride | 2016-07-05
REPOSITORIES: Pride
The Inge I Ruijtenberg Suzan S Bouchet Benjamin P BP Cristobal Alba A Prinsen Martine B W MB van Mourik Tim T Koreth John J Xu Huihong H Heck Albert J R AJ Akhmanova Anna A Cuppen Edwin E Boxem Mike M Muñoz Javier J van den Heuvel Sander S
Nature communications 20150106
Cyclin-dependent kinases 4 and 6 (CDK4/6) in complex with D-type cyclins promote cell cycle entry. Most human cancers contain overactive CDK4/6-cyclin D, and CDK4/6-specific inhibitors are promising anti-cancer therapeutics. Here, we investigate the critical functions of CDK4/6-cyclin D kinases, starting from an unbiased screen in the nematode Caenorhabditis elegans. We found that simultaneous mutation of lin-35, a retinoblastoma (Rb)-related gene, and fzr-1, an orthologue to the APC/C co-activa ...[more]