Proteomics

Dataset Information

72

Leukaemic protein tyrosine kinase comparison in Ba/F3 cells


ABSTRACT: Taking a series of oncogenic protein tyrosine kinases and constitutively expressing them in Ba/F3 cells, proteomic analysis was utilised in order to identify common protein changes.

INSTRUMENT(S): TripleTOF 5600, QSTAR

ORGANISM(S): Mus musculus  

TISSUE(S): Blood

DISEASE(S): Chronic Myeloid Leukemia

SUBMITTER: Andrew Williamson  

LAB HEAD: Prof. Anthony David Whetton

PROVIDER: PXD001505 | Pride | 2016-06-03

REPOSITORIES: pride

altmetric image

Publications


Chronic myeloid leukaemia (CML) arises after transformation of a haemopoietic stem cell (HSC) by the protein-tyrosine kinase BCR-ABL. Direct inhibition of BCR-ABL kinase has revolutionized disease management, but fails to eradicate leukaemic stem cells (LSCs), which maintain CML. LSCs are independent of BCR-ABL for survival, providing a rationale for identifying and targeting kinase-independent pathways. Here we show--using proteomics, transcriptomics and network analyses--that in human LSCs, ab  ...[more]

Similar Datasets

2016-01-01 | S-EPMC4982590 | BioStudies
2017-01-01 | S-EPMC5355038 | BioStudies
2018-01-01 | S-EPMC6188142 | BioStudies
2014-01-01 | S-EPMC5528641 | BioStudies
2011-01-01 | S-EPMC3084928 | BioStudies
2012-01-01 | S-EPMC3437859 | BioStudies
1000-01-01 | S-EPMC1392603 | BioStudies
2005-01-01 | S-EPMC1188271 | BioStudies
2011-01-01 | S-EPMC3105656 | BioStudies
| GSE62822 | GEO