Interactome analysis of PYHIN immune regulators

ABSTRACT: The human PYHIN proteins, AIM2, IFI16, IFIX, and MNDA, are regulators of immune response, transcription, apoptosis, and cell cycle. However, their protein interactions and underlying mechanisms remain largely uncharacterized. Here, we provide the interaction network for all PYHIN proteins. By designing a cell-based inducible system and integrating microscopy, immunoaffinity capture, quantitative mass spectrometry, and bioinformatics, we identified over 300 PYHIN interactions reflective of diverse functions.

OTHER RELATED OMICS DATASETS IN: MSV000079955

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Kidney Cell

SUBMITTER: Todd Greco  

LAB HEAD: Ileana M Cristea

PROVIDER: PXD001572 | Pride | 2015-03-12

REPOSITORIES: Pride