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RhoA ko BMDC - Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA

ABSTRACT: Differential protein expression between RhoA ko and wt bone marrow-derived dendritic cells

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Dendritic Cell, Cell Culture

SUBMITTER: Shuai Li

LAB HEAD: Thomas Brocker

PROVIDER: PXD001636 | Pride | 2015-10-01

REPOSITORIES: Pride

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Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA.

Li Shuai S Dislich Bastian B Brakebusch Cord H CH Lichtenthaler Stefan F SF Brocker Thomas T

Journal of immunology (Baltimore, Md. : 1950) 20150925 9

Tissues accommodate defined numbers of dendritic cells (DCs) in highly specific niches where different intrinsic and environmental stimuli control DC life span and numbers. DC homeostasis in tissues is important, because experimental changes in DC numbers influence immunity and tolerance toward various immune catastrophes and inflammation. However, the precise molecular mechanisms regulating DC life span and homeostasis are unclear. We report that the GTPase RhoA controls homeostatic proliferati ...[more]

PMID: 26408665

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