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Synaptosome Proteomics, Fraction 2

ABSTRACT: Synaptosomes were isolated by Percoll gradient centrigation and iTRAQ based nanoLC-MS/MS proteomics. Three synapse fractions were studied from three kind of experimental rat groups namely, stressed with anhedonia, stress resilient and unstressed controls.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

DISEASE(S): Mental Depression

SUBMITTER: Johan Palmfeldt

LAB HEAD: Johan Palmfeldt

PROVIDER: PXD001775 | Pride | 2016-04-26

REPOSITORIES: Pride

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Protein biomarkers of susceptibility and resilience to stress in a rat model of depression.

Palmfeldt Johan J Henningsen Kim K Eriksen Stine Aistrup SA Müller Heidi K HK Wiborg Ove O

Molecular and cellular neurosciences 20160420

The molecular etiologies of psychological stress and major depressive disorder (MDD) are highly complex and many brain regions are involved. The prefrontal cortex (PFC) has gained attention in depression research due to its role in cognition including working memory and decision-making, which are impaired in MDD. The aim of the present study was to identify differentially regulated synaptosomal proteins from PFC in stress-exposed animals. The well-established chronic mild stress (CMS) rodent mod ...[more]

PMID: 27105822

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