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Human Blood Serum LC-MS/MS - Serological epithelial component proteins identify intestinal complications in Crohn's Disease

ABSTRACT: Quantitative proteome profiling was performed on Inflammatory (ICD), stricturing and fistulizing Crohn's Disease serums using label-free Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).

INSTRUMENT(S): LTQ FT

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Blood Serum

DISEASE(S): Crohn's Disease

SUBMITTER: Yunki Yau

LAB HEAD: Mark Raftery

PROVIDER: PXD001821 | Pride | 2017-05-15

REPOSITORIES: Pride

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Serological Epithelial Component Proteins Identify Intestinal Complications in Crohn's Disease.

Yau Yunki Y YY Leong Rupert W L RWL Pudipeddi Aviv A Redmond Diane D Wasinger Valerie C VC

Molecular & cellular proteomics : MCP 20170510 7

Crohn's Disease (CD) is a relapsing inflammation of the gastrointestinal tract that affects a young working age population and is increasing in developing countries. Half of all sufferers will experience stricturing or fistulizing intestinal complications that require extensive surgical interventions and neither genes nor clinical risk factors can predict this debilitating natural history. We applied discovery and verification phase studies as part of an NCI-FDA modeled biomarker pipeline to ide ...[more]

PMID: 28490445

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