Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA266296PRJNA266245PRJNA266244PRJNA266297PRJNA266243
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Primary Cell, T Cell, Cell Culture
SUBMITTER: Thomas Whisenant
LAB HEAD: Daniel R. Salomon, M.D.
PROVIDER: PXD001843 | Pride | 2016-04-27
REPOSITORIES: Pride
Whisenant Thomas C TC Peralta Eigen R ER Aarreberg Lauren D LD Gao Nina J NJ Head Steven R SR Ordoukhanian Phillip P Williamson Jamie R JR Salomon Daniel R DR
PloS one 20151207 12
Activation of CD4 T cells is a reaction to challenges such as microbial pathogens, cancer and toxins that defines adaptive immune responses. The roles of T cell receptor crosslinking, intracellular signaling, and transcription factor activation are well described, but the importance of post-transcriptional regulation by RNA-binding proteins (RBPs) has not been considered in depth. We describe a new model expanding and activating primary human CD4 T cells and applied this to characterizing activa ...[more]