Dataset Information

S. cerevisiae subjected to prolonged heat stress of 37 ºC

ABSTRACT: Differential proteome composition of wild-type yeast cells (S. cerevisiae BY4741) grown at 30 ºC or 37 ºC was studied using SILAC based quantitative proteomics.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)

TISSUE(S): Cell Culture

SUBMITTER: Kshitiz Tyagi

LAB HEAD: Patrick G.A. Pedrioli

PROVIDER: PXD001864 | Pride | 2015-04-23

REPOSITORIES: Pride

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Publications

Protein degradation and dynamic tRNA thiolation fine-tune translation at elevated temperatures.

Tyagi Kshitiz K Pedrioli Patrick G A PG

Nucleic acids research 20150413 9

Maintenance of protein quality control has implications in various processes such as neurodegeneration and ageing. To investigate how environmental insults affect this process, we analysed the proteome of yeast continuously exposed to mild heat stress. In agreement with previous transcriptomics studies, amongst the most marked changes, we found up-regulation of cytoprotective factors; a shift from oxidative phosphorylation to fermentation; and down-regulation of translation. Importantly, we also ...[more]

PMID: 25870413

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Dataset Information

S. cerevisiae subjected to prolonged heat stress of 37 ºC

Publications

Protein degradation and dynamic tRNA thiolation fine-tune translation at elevated temperatures.

Similar Datasets

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