Proteomics

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S54-dependent response to nitrogen limitation and virulence in Burkholderia cenocepacia H111


ABSTRACT: Using a discovery shotgun proteomics approach, the expressed proteome of Burkholderia cenocepacia (strain H111) was analyzed under normal and starved nitrogen growth conditions. B. cenocepacia is an opportunistic human pathogen that is particularly problematic for patients suffering from cystic fibrosis.

OTHER RELATED OMICS DATASETS IN: E-GEOD-66328

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Burkholderia cenocepacia H111  

TISSUE(S): Tissue Not Applicable To Dataset

DISEASE(S): Not Available

SUBMITTER: Ulrich Goldmann  

LAB HEAD: Gabriella Pessi

PROVIDER: PXD001924 | Pride | 2015-05-05

REPOSITORIES: pride

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Publications

σ54-Dependent Response to Nitrogen Limitation and Virulence in Burkholderia cenocepacia Strain H111.

Lardi Martina M   Aguilar Claudio C   Pedrioli Alessandro A   Omasits Ulrich U   Suppiger Angela A   Cárcamo-Oyarce Gerardo G   Schmid Nadine N   Ahrens Christian H CH   Eberl Leo L   Pessi Gabriella G  

Applied and environmental microbiology 20150403 12


Members of the genus Burkholderia are versatile bacteria capable of colonizing highly diverse environmental niches. In this study, we investigated the global response of the opportunistic pathogen Burkholderia cenocepacia H111 to nitrogen limitation at the transcript and protein expression levels. In addition to a classical response to nitrogen starvation, including the activation of glutamine synthetase, PII proteins, and the two-component regulatory system NtrBC, B. cenocepacia H111 also upreg  ...[more]

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