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Legionella pneumophila proteome

ABSTRACT: Legionella pneumophila cells were harvested during exponential growth (RP) and stationary growth (TP). VBNC cells were also anylzed. Protein subfractions were studied.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Legionella Pneumophila Subsp. Pneumophila (strain Philadelphia 1 / Atcc 33152 / Dsm 7513)

TISSUE(S): Cell

SUBMITTER: Birgit Voigt

LAB HEAD: Miacheal Hecker

PROVIDER: PXD001926 | Pride | 2015-11-13

REPOSITORIES: Pride

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Life Stage-specific Proteomes of Legionella pneumophila Reveal a Highly Differential Abundance of Virulence-associated Dot/Icm effectors.

Aurass Philipp P Gerlach Thomas T Becher Dörte D Voigt Birgit B Karste Susanne S Bernhardt Jörg J Riedel Katharina K Hecker Michael M Flieger Antje A

Molecular & cellular proteomics : MCP 20151106 1

Major differences in the transcriptional program underlying the phenotypic switch between exponential and post-exponential growth of Legionella pneumophila were formerly described characterizing important alterations in infection capacity. Additionally, a third state is known where the bacteria transform in a viable but nonculturable state under stress, such as starvation. We here describe phase-related proteomic changes in exponential phase (E), postexponential phase (PE) bacteria, and uncultur ...[more]

PMID: 26545400

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