Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell
DISEASE(S): Osteosarcoma
SUBMITTER: Francois-Michel Boisvert
LAB HEAD: Francois-Michel Boisvert
PROVIDER: PXD001949 | Pride | 2017-12-06
REPOSITORIES: Pride
Drissi Romain R Dubois Marie-Line ML Douziech Mélanie M Boisvert François-Michel FM
Molecular & cellular proteomics : MCP 20150511 7
The minichromosome maintenance complex (MCM) proteins are required for processive DNA replication and are a target of S-phase checkpoints. The eukaryotic MCM complex consists of six proteins (MCM2-7) that form a heterohexameric ring with DNA helicase activity, which is loaded on chromatin to form the pre-replication complex. Upon entry in S phase, the helicase is activated and opens the DNA duplex to recruit DNA polymerases at the replication fork. The MCM complex thus plays a crucial role durin ...[more]