Molecular signatures after challenge with Salmonella Typhi implicate host tryptophan metabolism in the pathogenesis of typhoid fever, part 1

ABSTRACT: Induced pluripotent stem (iPS) cell derived human macrophages were stimulated with IFN-y or exposed to viable S. Typhimurium SL1344 using either a gentamicin invasion assay or after over-night priming with IFN-y. Protein abundance changes between samples was determined relative to unstimulated controls using TMT labelling and mass spectrometry.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Macrophage

DISEASE(S): Salmonella Infectious Disease

SUBMITTER: James Wright  

LAB HEAD: Jyoti Choudhary

PROVIDER: PXD001953 | Pride | 2016-05-31

REPOSITORIES: Pride