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Molecular signatures after challenge with Salmonella Typhi implicate host tryptophan metabolism in the pathogenesis of typhoid fever, part 2

ABSTRACT: Label free quantitation using DIA HDMSe of Salmonella infected and uninfected mouse caecum tissue

INSTRUMENT(S): Synapt MS

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cecum

DISEASE(S): Salmonella Infectious Disease

SUBMITTER: James Wright

LAB HEAD: Jyoti Choudhary

PROVIDER: PXD001954 | Pride | 2020-01-21

REPOSITORIES: Pride

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Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever.

Blohmke Christoph J CJ Darton Thomas C TC Jones Claire C Suarez Nicolas M NM Waddington Claire S CS Angus Brian B Zhou Liqing L Hill Jennifer J Clare Simon S Kane Leanne L Mukhopadhyay Subhankar S Schreiber Fernanda F Duque-Correa Maria A MA Wright James C JC Roumeliotis Theodoros I TI Yu Lu L Choudhary Jyoti S JS Mejias Asuncion A Ramilo Octavio O Shanyinde Milensu M Sztein Marcelo B MB Kingsley Robert A RA Lockhart Stephen S Levine Myron M MM Lynn David J DJ Dougan Gordon G Pollard Andrew J AJ

The Journal of experimental medicine 20160523 6

Enteric fever, caused by Salmonella enterica serovar Typhi, is an important public health problem in resource-limited settings and, despite decades of research, human responses to the infection are poorly understood. In 41 healthy adults experimentally infected with wild-type S. Typhi, we detected significant cytokine responses within 12 h of bacterial ingestion. These early responses did not correlate with subsequent clinical disease outcomes and likely indicate initial host-pathogen interactio ...[more]

PMID: 27217537

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