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Cooperative target mRNA destabilization and translation inhibition by miR-58 microRNA family in C. elegans

ABSTRACT: Comparative proteomic study between C. elegans wild type, mir-58.1 single, mir-80; mir-58.1 double and mir-80; mir-58.1; mir-81-82 quadruple mutants.

OTHER RELATED OMICS DATASETS IN: PRJNA258285PRJNA258215PRJNA258214

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Caenorhabditis Elegans

TISSUE(S): Whole Body

SUBMITTER: Yibo Wu

LAB HEAD: Yibo Wu

PROVIDER: PXD001998 | Pride | 2015-08-06

REPOSITORIES: Pride

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Cooperative target mRNA destabilization and translation inhibition by miR-58 microRNA family in C. elegans.

Subasic Deni D Brümmer Anneke A Wu Yibo Y Pinto Sérgio Morgado SM Imig Jochen J Keller Martin M Jovanovic Marko M Lightfoot Helen Louise HL Nasso Sara S Goetze Sandra S Brunner Erich E Hall Jonathan J Aebersold Ruedi R Zavolan Mihaela M Hengartner Michael O MO

Genome research 20150731 11

In animals, microRNAs frequently form families with related sequences. The functional relevance of miRNA families and the relative contribution of family members to target repression have remained, however, largely unexplored. Here, we used the Caenorhabditis elegans miR-58 miRNA family, composed primarily of the four highly abundant members miR-58.1, miR-80, miR-81, and miR-82, as a model to investigate the redundancy of miRNA family members and their impact on target expression in an in vivo s ...[more]

PMID: 26232411

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Cooperative target mRNA destabilization and translation inhibition by miR-58 microRNA family in C. elegans [RNA-Seq]

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