Trypanosoma brucei extracellular vesicles
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Trypanosoma Brucei
DISEASE(S): Trypanosomiasis
SUBMITTER: 
Ernesto Nakayasu
LAB HEAD: Igor C. Almeida
PROVIDER: PXD002030 | Pride | 2016-01-27
REPOSITORIES: Pride
Publications
Extracellular Vesicles from Trypanosoma brucei Mediate Virulence Factor Transfer and Cause Host Anemia.
Szempruch Anthony J AJ Sykes Steven E SE Kieft Rudo R Dennison Lauren L Becker Allison C AC Gartrell Anzio A Martin William J WJ Nakayasu Ernesto S ES Almeida Igor C IC Hajduk Stephen L SL Harrington John M JM
Cell 20160101 1-2
Intercellular communication between parasites and with host cells provides mechanisms for parasite development, immune evasion, and disease pathology. Bloodstream African trypanosomes produce membranous nanotubes that originate from the flagellar membrane and disassociate into free extracellular vesicles (EVs). Trypanosome EVs contain several flagellar proteins that contribute to virulence, and Trypanosoma brucei rhodesiense EVs contain the serum resistance-associated protein (SRA) necessary for ...[more]
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