Proteomics

Dataset Information

84

Tau interactome - The human tau interactome: binding to the ribonucleoproteome, and impaired binding of the P301L mutant to chaperones and the proteasome


ABSTRACT: The tau protein is central to the etiology of several neurodegenerative diseases, including Alzheimer’s disease, a subset of frontotemporal dementias, progressive supranuclear palsy and dementia following traumatic brain injury, yet the proteins it interacts with have not been studied using a systematic discovery approach. The study employed mild in vivo crosslinking, isobaric labeling and tandem mass spectrometry to characterize molecular interactions of human tau in a neuroblastoma cell model.

REANALYSED by: GPM32320017706

INSTRUMENT(S): Orbitrap Fusion ETD

ORGANISM(S): Homo sapiens  

TISSUE(S): Cell Culture

DISEASE(S): Alzheimer's Disease

SUBMITTER: Gerold Schmitt-Ulms  

LAB HEAD: Gerold Schmitt-Ulms

PROVIDER: PXD002058 | Pride | 2015-08-17

REPOSITORIES: Pride

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Publications

The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome.

Gunawardana C Geeth CG   Mehrabian Mohadeseh M   Wang Xinzhu X   Mueller Iris I   Lubambo Isabela B IB   Jonkman James E N JE   Wang Hansen H   Schmitt-Ulms Gerold G  

Molecular & cellular proteomics : MCP 20150811 11


The tau protein is central to the etiology of several neurodegenerative diseases, including Alzheimer's disease, a subset of frontotemporal dementias, progressive supranuclear palsy and dementia following traumatic brain injury, yet the proteins it interacts with have not been studied using a systematic discovery approach. Here we employed mild in vivo crosslinking, isobaric labeling, and tandem mass spectrometry to characterize molecular interactions of human tau in a neuroblastoma cell model.  ...[more]

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