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Proteome profiling upon Myc activation

ABSTRACT: The effect of Myc activation on the proteome was investigated in U2OS cells and proteome changes were combined with Ribo-seq, RNA-seq and GRO-seq analyses.

OTHER RELATED OMICS DATASETS IN: PRJNA278391PRJNA278389PRJNA278390PRJNA277965

INSTRUMENT(S): Orbitrap Fusion ETD

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Bone Cancer

SUBMITTER: Onno Bleijerveld

LAB HEAD: A.F. Maarten Altelaar

PROVIDER: PXD002073 | Pride | 2015-11-09

REPOSITORIES: Pride

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Myc coordinates transcription and translation to enhance transformation and suppress invasiveness.

Elkon Ran R Loayza-Puch Fabricio F Korkmaz Gozde G Lopes Rui R van Breugel Pieter C PC Bleijerveld Onno B OB Altelaar A F Maarten AF Wolf Elmar E Lorenzin Francesca F Eilers Martin M Agami Reuven R

EMBO reports 20151104 12

c-Myc is one of the major human proto-oncogenes and is often associated with tumor aggression and poor clinical outcome. Paradoxically, Myc was also reported as a suppressor of cell motility, invasiveness, and metastasis. Among the direct targets of Myc are many components of the protein synthesis machinery whose induction results in an overall increase in protein synthesis that empowers tumor cell growth. At present, it is largely unknown whether beyond the global enhancement of protein synthes ...[more]

PMID: 26538417

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