Dataset Information
CPTAC, TCGA Cancer Proteome Study of Colorectal Tissue: Proteome, VU, part 5
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Rectal Cancer Cell, Colonic Cancer Cell
DISEASE(S): Colon Adenocarcinoma,Rectum Adenocarcinoma
SUBMITTER: 
Nathan Edwards
LAB HEAD: Daniel C. Liebler, Ph.D.
PROVIDER: PXD002084 | Pride | 2015-07-06
REPOSITORIES: Pride
Publications
Proteogenomic characterization of human colon and rectal cancer.
Nature 20140720 7518
Extensive genomic characterization of human cancers presents the problem of inference from genomic abnormalities to cancer phenotypes. To address this problem, we analysed proteomes of colon and rectal tumours characterized previously by The Cancer Genome Atlas (TCGA) and perform integrated proteogenomic analyses. Somatic variants displayed reduced protein abundance compared to germline variants. Messenger RNA transcript abundance did not reliably predict protein abundance differences between tu ...[more]