Proteomics

Dataset Information

603

Zebrafish embryo_phosphorylation_18O labeling


ABSTRACT: The zebrafish (Danio rerio) is a popular animal model in studies of vertebrate development and organogenesis. Recent research has shown a similarity of approximately 70% between the human and zebrafish genomes and of 84% in human disease-causing genes, specifically. Zebrafish embryos have a number of desirable features, including transparency, a large size, and rapid embryogenesis. Protein phosphorylation is a well-known post-translational modification (PTM), which performs various biological functions. Recent mass spectrometry (MS) developments have enabled the study of global phosphorylation patterns by using MS-based proteomics coupled with TiO2 phosphopeptide enrichment. In the present study, we identified 3,500 non-redundant phosphorylation sites on 2,166 phosphoproteins and 1,564 quantified phosphoproteins in zebrafish embryos.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Danio rerio  

TISSUE(S): Embryo

DISEASE(S): Not Available

SUBMITTER: Oh Kwang Kwon  

LAB HEAD: Sangkyu Lee

PROVIDER: PXD002232 | Pride | 2015-10-14

REPOSITORIES: Pride

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Publications

Global analysis of phosphoproteome dynamics in embryonic development of zebrafish (Danio rerio).

Kwon Oh Kwang OK   Kim Sun Ju SJ   Lee You-Mie YM   Lee Young-Hoon YH   Bae Young-Seuk YS   Kim Jin Young JY   Peng Xiaojun X   Cheng Zhongyi Z   Zhao Yingming Y   Lee Sangkyu S  

Proteomics 20151207 1


The zebrafish (Danio rerio) is a popular animal model used for studies on vertebrate development and organogenesis. Recent research has shown a similarity of approximately 70% between the human and zebrafish genomes and about 84% of human disease-causing genes have common ancestry with that of the zebrafish genes. Zebrafish embryos have a number of desirable features, including transparency, a large size, and rapid embryogenesis. Protein phosphorylation is a well-known PTM, which can carry out v  ...[more]

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