Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Plasmodium Falciparum
TISSUE(S): Blood
SUBMITTER: Andrew Bottrill
LAB HEAD: Professor Andrew B. Tobin
PROVIDER: PXD002266 | Pride | 2017-09-22
REPOSITORIES: Pride
Alam Mahmood M MM Solyakov Lev L Bottrill Andrew R AR Flueck Christian C Siddiqui Faiza A FA Singh Shailja S Mistry Sharad S Viskaduraki Maria M Lee Kate K Hopp Christine S CS Chitnis Chetan E CE Doerig Christian C Moon Robert W RW Green Judith L JL Holder Anthony A AA Baker David A DA Tobin Andrew B AB
Nature communications 20150707
Our understanding of the key phosphorylation-dependent signalling pathways in the human malaria parasite, Plasmodium falciparum, remains rudimentary. Here we address this issue for the essential cGMP-dependent protein kinase, PfPKG. By employing chemical and genetic tools in combination with quantitative global phosphoproteomics, we identify the phosphorylation sites on 69 proteins that are direct or indirect cellular targets for PfPKG. These PfPKG targets include proteins involved in cell signa ...[more]