Proteomics

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Chicken embryo proteome - Quantitative Mass Spectrometry Reveals Partial Translational Regulation for Dosage Compensation in Chicken

ABSTRACT: White Leghorn chicken eggs were incubated for 18 days and dissected. Brain, breast muscle, bursa Fabricii, heart, kidney, liver, lung, ovary, spleen, and testicle tissues were sampled.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Gallus Gallus (chicken)

TISSUE(S): Spleen, Heart, Testis, Ovary, Brain, Lung, Liver, Pectoral Muscle, Bursa Of Fabricius, Kidney

SUBMITTER: Jia Mi  

LAB HEAD: Jonas Bergquist

PROVIDER: PXD002403 | Pride | 2015-07-15

REPOSITORIES: Pride

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Publications

Quantitative Mass Spectrometry Reveals Partial Translational Regulation for Dosage Compensation in Chicken.

Uebbing Severin S   Konzer Anne A   Xu Luohao L   Backström Niclas N   Brunström Björn B   Bergquist Jonas J   Ellegren Hans H  

Molecular biology and evolution 20150624 10

There is increasing evidence that dosage compensation is not a ubiquitous feature following sex chromosome evolution, especially not in organisms where females are the heterogametic sex, like in birds. Even when it occurs, compensation can be incomplete and limited to dosage-sensitive genes. However, previous work has mainly studied transcriptional regulation of sex-linked genes, which may not reflect expression at the protein level. Here, we used liquid chromatography-tandem mass spectrometry t  ...[more]