Proteomics

Dataset Information

83

Global quantitative proteomic analysis of human glioma cells profiled host protein expression in response to enterovirus type 71 infection


ABSTRACT: Enterovirus 71 (EV71) is one of the leading causes of hand, foot and mouth disease with neurological complications in some cases. To study the pathogenesis of EV71 infection, large scale analyses of EV71 infected cells have been performed. However, most of these studies employed rhabdomyosarcoma (RD) cells or used transcriptomic strategy. Here, we performed SILAC-based quantitative proteomic analysis of EV71-infected U251 cells, a human glioma cell line. A total of 3,125 host proteins were quantified, 451 of which were differentially regulated as a result of EV71 infection at 8 hpi or 20 hpi or both.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Lei-Ke Zhang  

LAB HEAD: Lei-Ke Zhang

PROVIDER: PXD002454 | Pride | 2015-09-15

REPOSITORIES: Pride

Dataset's files

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20140418_AN1.wiff Wiff
20140418_AN1.wiff.scan Wiff
20140418_AN1__FDR.xlsx Xlsx
20140418_AN2.wiff Wiff
20140418_AN2.wiff.scan Wiff
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Global quantitative proteomic analysis of human glioma cells profiled host protein expression in response to enterovirus type 71 infection.

Zhang Lei-Ke LK   Lin Tao T   Zhu Sheng-Lin SL   Xianyu Ling-Zhi LZ   Lu Song-Ya SY  

Proteomics 20151016 22


Enterovirus 71 (EV71) is one of the leading causes of hand, foot and mouth disease with neurological complications in some cases. To study the pathogenesis of EV71 infection, large-scale analyses of EV71 infected cells have been performed. However, most of these studies employed rhabdomyosarcoma (RD) cells or used transcriptomic strategy. Here, we performed SILAC-based quantitative proteomic analysis of EV71-infected U251 cells, a human glioma cell line. A total of 3125 host proteins were quanti  ...[more]

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