Target identification for 11q13 amplicon

ABSTRACT: Proteomic strategy to define therapeutically relevant targets in cell lines that contain the 11q13 amplicon compared to those that do not and to ascertain which genes are amplified at the protein level and, concomitantly, are key drivers for tumor growth and/or maintenance. Furthermore, so called passenger genes that are amplified with driver genes and a manifest on the cell surface can be attractive targets for an antibody – drug conjugate approach (ADC).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Neck Carcinoma

SUBMITTER: Heather Hoover  

LAB HEAD: Nancy Finkel

PROVIDER: PXD002486 | Pride | 2015-08-04

REPOSITORIES: Pride