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Proteome profiling of GC1-spg cells over-expressing Autoimmune Regulator (AIRE)

ABSTRACT: This project was aimed at evaluating the influence of Autoimmune Regulator in gene expression in GC1-spg cells.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Testis, Spermatogonium

SUBMITTER: Pradeep Kumar

LAB HEAD: Dr. Pradeep G. Kumar

PROVIDER: PXD002511 | Pride | 2016-06-14

REPOSITORIES: Pride

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Autoimmune Regulator (AIRE) Is Expressed in Spermatogenic Cells, and It Altered the Expression of Several Nucleic-Acid-Binding and Cytoskeletal Proteins in Germ Cell 1 Spermatogonial (GC1-spg) Cells.

Radhakrishnan Karthika K Bhagya Kongattu P KP Kumar Anil Tr AT Devi Anandavalli N AN Sengottaiyan Jeeva J Kumar Pradeep G PG

Molecular & cellular proteomics : MCP 20160608 8

Autoimmune regulator (AIRE) is a gene associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). AIRE is expressed heavily in the thymic epithelial cells and is involved in maintaining self-tolerance through regulating the expression of tissue-specific antigens. The testes are the most predominant extrathymic location where a heavy expression of AIRE is reported. Homozygous Aire-deficient male mice were infertile, possibly due to impaired spermatogenesis, deregulate ...[more]

PMID: 27281783

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