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Human Brain LC-MS/MS - Dementia-linked amyloidosis is associated with brain protein deamidation as revealed by proteomic profiling of human brain tissues

ABSTRACT: Brian Protein Deamidation Associated with Amyloidosis Revealed by Soluble and Amyloidal Brian Proteome Profiling

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Sunil Adav

LAB HEAD: Siu-Kwan Sze

PROVIDER: PXD002516 | Pride | 2016-08-24

REPOSITORIES: Pride

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Dementia-linked amyloidosis is associated with brain protein deamidation as revealed by proteomic profiling of human brain tissues.

Adav Sunil S SS Gallart-Palau Xavier X Tan Kok Hian KH Lim Sai Kiang SK Tam James P JP Sze Siu Kwan SK

Molecular brain 20160219

<h4>Background</h4>Aggregation of malformed proteins is a key feature of many neurodegenerative diseases, but the mechanisms that drive proteinopathy in the brain are poorly understood. We aimed to characterize aggregated proteins in human brain tissues affected by dementia.<h4>Results</h4>To characterize amyloidal plaque purified from post-mortem brain tissue of dementia patient, we applied ultracentrifugation-electrostatic repulsion hydrophilic interaction chromatography (UC-ERLIC) coupled mas ...[more]

PMID: 26892330

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