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Extracellular Matrix Analysis of Human Varicose Veins

ABSTRACT: To understand the consequences of venous hypertension, normal and varicose veins were evaluated using proteomics approaches targeting the extracellular matrix.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Great Saphenous Vein

DISEASE(S): Varicose Veins

SUBMITTER: Xiaoke Yin

LAB HEAD: Manuel Mayr

PROVIDER: PXD002555 | Pride | 2016-05-03

REPOSITORIES: Pride

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Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.

Barallobre-Barreiro Javier J Oklu Rahmi R Lynch Marc M Fava Marika M Baig Ferheen F Yin Xiaoke X Barwari Temo T Potier David N DN Albadawi Hassan H Jahangiri Marjan M Porter Karen E KE Watkins Michael T MT Misra Sanjay S Stoughton Julianne J Mayr Manuel M

Cardiovascular research 20160411 3

<h4>Aims</h4>Extracellular matrix remodelling has been implicated in a number of vascular conditions, including venous hypertension and varicose veins. However, to date, no systematic analysis of matrix remodelling in human veins has been performed.<h4>Methods and results</h4>To understand the consequences of venous hypertension, normal and varicose veins were evaluated using proteomics approaches targeting the extracellular matrix. Varicose saphenous veins removed during phlebectomy and normal ...[more]

PMID: 27068509

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