Proteomics

Dataset Information

A Conformationally Arrested Peptidomimetic Antibiotic Disrupts Selectively the Outer Membrane in Escherichia coli

ABSTRACT: Using a shotgun proteomics approach, the expressed proteome of total membrane fractions of Escherichia coli ATCC25922 cells was analyzed under i) normal growth, and ii) treatment with the novel peptidomimetic JB-95 (a structurally arrested cyclic peptide). By selectively disrupturing the outer membrane (OM), this peptidomimetic displayed a novel mechanism of action and opens new avenues for developing antibiotics that specifically target the OM of Gram-negative bacteria.

INSTRUMENT(S):

ORGANISM(S): Escherichia Coli

SUBMITTER: Christian Ahrens  

LAB HEAD: Prof. John Robinson

PROVIDER: PXD002588 | Pride | 2015-12-07

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
20130311_02_memA1.RAW Raw
20130311_02_memA1.mgf Mgf
20130311_02_memA1.mgf.msgfplus_20ppm.mzid.gz Mzid
20130311_02_memA1.mgf.msgfplus_20ppm.pride.mztab.gz Mztab
20130311_02_memA1.pride.mgf.gz Mgf
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