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Proteome profiling of GC1-spg cells over-expressing DYNLT1

ABSTRACT: This study was designed to evaluate the proteome profiles of GC1-spg cells transfected with pEGFPN1-dynlt1 (experiment) and empty vector (control). The cells were harvested 48 hrs after transfection and the proteins were profiled.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Testis, Spermatogonium

SUBMITTER: Pradeep Kumar

LAB HEAD: Dr. Pradeep G Kumar

PROVIDER: PXD002593 | Pride | 2015-11-03

REPOSITORIES: Pride

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Aberrant Expression of Dynein light chain 1 (DYNLT1) is Associated with Human Male Factor Infertility.

Indu Sivankutty S Sekhar Sreeja C SC Sengottaiyan Jeeva J Kumar Anil A Pillai Sathy M SM Laloraya Malini M Kumar Pradeep G PG

Molecular & cellular proteomics : MCP 20151002 12

DYNLT1 is a member of a gene family identified within the t-complex of the mouse, which has been linked with male germ cell development and function in the mouse and the fly. Though defects in the expression of this gene are associated with male sterility in both these models, there has been no study examining its association with spermatogenic defects in human males. In this study, we evaluated the levels of DYNLT1 and its expression product in the germ cells of fertile human males and males su ...[more]

PMID: 26432663

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