Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood
SUBMITTER: Andrea Petretto
LAB HEAD: Andrea Petretto
PROVIDER: PXD002629 | Pride | 2018-10-24
REPOSITORIES: Pride
Bertaina A A Zorzoli A A Petretto A A Barbarito G G Inglese E E Merli P P Lavarello C C Brescia L P LP De Angelis B B Tripodi G G Moretta L L Locatelli F F Airoldi I I
Oncoimmunology 20160927 2
We demonstrated that γδ T cells of patients given HLA-haploidentical HSCT after removal of αβ<sup>+</sup> T cells and CD19<sup>+</sup> B cells are endowed with the capacity of killing leukemia cells after <i>ex vivo</i> treatment with zoledronic acid (ZOL). Thus, we tested the hypothesis that infusion of ZOL in patients receiving this type of graft may enhance γδ T-cell cytotoxic activity against leukemia cells. ZOL was infused every 28 d in 43 patients; most were treated at least twice. γδ T ce ...[more]