Proteomics

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Human γδ T-cell, LC-MS/MS - Zoledronic acid boosts γδ T-cell activity in children receiving αβ+ T and CD19+ cell-depleted grafts from an HLA-haplo-identical donor


ABSTRACT: A new method of graft manipulation based on physical removal of αβ+ T cells and CD19+ B cells, leaving mature NK cells and γδ T cells in the graft, has been recently developed for HLA-haploidentical HSCT. We demonstrated that γδ T cells collected from transplanted patients are endowed with capacity of killing leukemia cells after ex vivo treatment with zoledronic acid (ZOL). Thus, we hypothesized that infusion of ZOL in patients receiving this type of graft, may boost γδ T cell cytotoxic activity against acute leukemia blasts.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood

SUBMITTER: Andrea Petretto  

LAB HEAD: Andrea Petretto

PROVIDER: PXD002629 | Pride | 2018-10-24

REPOSITORIES: Pride

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Zoledronic acid boosts γδ T-cell activity in children receiving αβ<sup>+</sup> T and CD19<sup>+</sup> cell-depleted grafts from an HLA-haplo-identical donor.

Bertaina A A   Zorzoli A A   Petretto A A   Barbarito G G   Inglese E E   Merli P P   Lavarello C C   Brescia L P LP   De Angelis B B   Tripodi G G   Moretta L L   Locatelli F F   Airoldi I I  

Oncoimmunology 20160927 2


We demonstrated that γδ T cells of patients given HLA-haploidentical HSCT after removal of αβ<sup>+</sup> T cells and CD19<sup>+</sup> B cells are endowed with the capacity of killing leukemia cells after <i>ex vivo</i> treatment with zoledronic acid (ZOL). Thus, we tested the hypothesis that infusion of ZOL in patients receiving this type of graft may enhance γδ T-cell cytotoxic activity against leukemia cells. ZOL was infused every 28 d in 43 patients; most were treated at least twice. γδ T ce  ...[more]

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