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Omics score: 139

Identification of differentially expressed proteins during the fermentation of Saccharopolyspora erythraea

ABSTRACT: At selected timepoints during the S erythrea fermentation process, samples of fermentation broth were collected. Proteins in the samples were separated by 2D-PAGE and differentially expressed proteins were identified by LC-MS/MS.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Saccharopolyspora Erythraea (streptomyces Erythraeus)

TISSUE(S): Cell Suspension Culture, Permanent Cell Line Cell

SUBMITTER: Marko Fonovic

LAB HEAD: dr. Marko Fonovic

PROVIDER: PXD002677 | Pride | 2016-05-26

REPOSITORIES: Pride

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Integrated omics approaches provide strategies for rapid erythromycin yield increase in Saccharopolyspora erythraea.

Karničar Katarina K Drobnak Igor I Petek Marko M Magdevska Vasilka V Horvat Jaka J Vidmar Robert R Baebler Špela Š Rotter Ana A Jamnik Polona P Fujs Štefan Š Turk Boris B Fonovič Marko M Gruden Kristina K Kosec Gregor G Petković Hrvoje H

Microbial cell factories 20160603

<h4>Background</h4>Omics approaches have significantly increased our understanding of biological systems. However, they have had limited success in explaining the dramatically increased productivity of commercially important natural products by industrial high-producing strains, such as the erythromycin-producing actinomycete Saccharopolyspora erythraea. Further yield increase is of great importance but requires a better understanding of the underlying physiological processes.<h4>Results</h4>To ...[more]

PMID: 27255285

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