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Proteomics of Secretomes and Exosomes in Melanoma

ABSTRACT: Exosomes were purified from several cell lines with different metastatic potential. Seecreted proteins were isolated from the same samples using the approach from Eichelbaum et al. Nat Biotechnol 2012

OTHER RELATED OMICS DATASETS IN: PRJNA371460

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Javier Munoz

LAB HEAD: Javier Munoz

PROVIDER: PXD002703 | Pride | 2017-06-29

REPOSITORIES: Pride

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Publications

Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine.

Olmeda David D Cerezo-Wallis Daniela D Riveiro-Falkenbach Erica E Pennacchi Paula C PC Contreras-Alcalde Marta M Ibarz Nuria N Cifdaloz Metehan M Catena Xavier X Calvo Tonantzin G TG Cañón Estela E Alonso-Curbelo Direna D Suarez Javier J Osterloh Lisa L Graña Osvaldo O Mulero Francisca F Megías Diego D Cañamero Marta M Martínez-Torrecuadrada Jorge L JL Mondal Chandrani C Di Martino Julie J Lora David D Martinez-Corral Inés I Bravo-Cordero J Javier JJ Muñoz Javier J Puig Susana S Ortiz-Romero Pablo P Rodriguez-Peralto José L JL Ortega Sagrario S Soengas María S MS

Nature 20170601 7660

Cutaneous melanoma is a type of cancer with an inherent potential for lymph node colonization, which is generally preceded by neolymphangiogenesis. However, sentinel lymph node removal does not necessarily extend the overall survival of patients with melanoma. Moreover, lymphatic vessels collapse and become dysfunctional as melanomas progress. Therefore, it is unclear whether (and how) lymphangiogenesis contributes to visceral metastasis. Soluble and vesicle-associated proteins secreted by tumou ...[more]

PMID: 28658220

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