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Plasma Proteome Profiling of CML in Pakistan

ABSTRACT: Systematic characterization of the plasma proteome in healthy and diseased state may uncover the potential biomarkers of disease diagnosis, prognosis and/or relapse detection. We, in this research project, have employed two-dimensional gel electrophoresis in conjunction with mass spectrometry-based analysis in a proteome-wide search for the identification of biomarkers of chronic-phase chronic myeloid leukemia (CP-CML).

INSTRUMENT(S): ultraflex

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Blood Plasma

DISEASE(S): Chronic Myeloid Leukemia

SUBMITTER: Muhammad Akhtar

LAB HEAD: Prof. Dr. M. Waheed Akhtar

PROVIDER: PXD002757 | Pride | 2017-01-30

REPOSITORIES: Pride

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CD5 molecule-like and transthyretin as putative biomarkers of chronic myeloid leukemia - an insight from the proteomic analysis of human plasma.

Fatima Iram I Sadaf Saima S Musharraf Syed Ghulam SG Hashmi Naghma N Akhtar Muhammad Waheed MW

Scientific reports 20170124

Better and sensitive biomarkers are needed to help understand the mechanism of disease onset, progression, prognosis and monitoring of the therapeutic response. Aim of this study was to identify the candidate circulating markers of chronic-phase chronic myeloid leukemia (CP-CML) manifestations, having potential to develop into predictive- or monitoring-biomarkers. A proteomic approach, two-dimensional gel electrophoresis in conjunction with mass spectrometry (2DE-MS), was employed for this purpo ...[more]

PMID: 28117336

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