Dataset Information
A Survey of Serine Hydrolase Activity in Mycobacterium tuberculosis
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Mycobacterium Tuberculosis
TISSUE(S): Blood Cell, Blood
DISEASE(S): Breast Cancer
SUBMITTER: 
Matthew Monroe
LAB HEAD: Aaron T. Wright
PROVIDER: PXD002763 | Pride | 2016-02-01
REPOSITORIES: Pride
Publications
Systematic Survey of Serine Hydrolase Activity in Mycobacterium tuberculosis Defines Changes Associated with Persistence.
Cell chemical biology 20160204 2
The transition from replication to non-replication underlies much of Mycobacterium tuberculosis (Mtb) pathogenesis, as non- or slowly replicating Mtb are responsible for persistence and poor treatment outcomes. Therapeutic targeting of non-replicating populations is a priority for tuberculosis treatment, but few drug targets in non-replicating Mtb are currently known. Here, we directly measured the activity of the highly diverse and druggable serine hydrolases (SHs) during active replication and ...[more]
