Proteomic profiling of retinoblastoma by high resolution mass spectrometry

ABSTRACT: We performed a high throughput comparative proteomics study to identify differentially expressed proteins that could serve as putative targets in retinoblastoma. We used iTRAQ based quantitative proteomics approach and analyzed the samples on orbitrap velos mass spectrometer. We identified and quantified a total of 3733 proteins in retinoblastoma when compared with normal adult retina. In total, we identified 987 proteins that were differentially expressed in retinoblastoma with a fold change of ≥2 of which 392 proteins were upregulated and 595 were downregulated.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Retina

DISEASE(S): Retinoblastoma

SUBMITTER: Sailaja Elchuri  

LAB HEAD: Dr. Sailaja V Elchuri

PROVIDER: PXD002774 | Pride | 2016-12-23

REPOSITORIES: Pride