Dataset Information
SCOPE 4 proteomics - Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells
Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA112367PRJNA132313PRJNA208363PRJNA96045
INSTRUMENT(S): QSTAR
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): B Cell, Blood
DISEASE(S): Acute Leukemia
SUBMITTER: 
Andrew Williamson
LAB HEAD: Prof. Tony Whetton
PROVIDER: PXD002782 | Pride | 2016-05-26
REPOSITORIES: Pride
Publications
Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells.
Nature 20160608 7607
Chronic myeloid leukaemia (CML) arises after transformation of a haemopoietic stem cell (HSC) by the protein-tyrosine kinase BCR-ABL. Direct inhibition of BCR-ABL kinase has revolutionized disease management, but fails to eradicate leukaemic stem cells (LSCs), which maintain CML. LSCs are independent of BCR-ABL for survival, providing a rationale for identifying and targeting kinase-independent pathways. Here we show--using proteomics, transcriptomics and network analyses--that in human LSCs, ab ...[more]
