Dataset Information

SCOPE 4 proteomics - Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells

ABSTRACT: BaF3 were transfected with Jak2 V617F, Jak2 K539L or Mpl W515L, shotgun proteomic analysis with iTRAQ was performed

OTHER RELATED OMICS DATASETS IN: PRJNA112367PRJNA132313PRJNA208363PRJNA96045

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): B Cell, Blood

DISEASE(S): Acute Leukemia

SUBMITTER: Andrew Williamson

LAB HEAD: Prof. Tony Whetton

PROVIDER: PXD002782 | Pride | 2016-05-26

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	012111_AP_Scope4.4_Cyto_17.mzML	Mzml
	012111_AP_Scope4.4_Cyto_17.wiff	Wiff
	012111_AP_Scope4.4_Cyto_17.wiff.scan	Wiff
	012111_AP_Scope4.4_Cyto_18.mzML	Mzml
	012111_AP_Scope4.4_Cyto_18.wiff	Wiff

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Publications

Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells.

Abraham Sheela A SA Hopcroft Lisa E M LE Carrick Emma E Drotar Mark E ME Dunn Karen K Williamson Andrew J K AJ Korfi Koorosh K Baquero Pablo P Park Laura E LE Scott Mary T MT Pellicano Francesca F Pierce Andrew A Copland Mhairi M Nourse Craig C Grimmond Sean M SM Vetrie David D Whetton Anthony D AD Holyoake Tessa L TL

Nature 20160608 7607

Chronic myeloid leukaemia (CML) arises after transformation of a haemopoietic stem cell (HSC) by the protein-tyrosine kinase BCR-ABL. Direct inhibition of BCR-ABL kinase has revolutionized disease management, but fails to eradicate leukaemic stem cells (LSCs), which maintain CML. LSCs are independent of BCR-ABL for survival, providing a rationale for identifying and targeting kinase-independent pathways. Here we show--using proteomics, transcriptomics and network analyses--that in human LSCs, ab ...[more]

PMID: 27281222

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