Tumor selective proteotoxicity of verteporfin inhibits colon cancer progression independent of YAP1

ABSTRACT: Verteporfin (VP) inhibts colon cancer growth in vivo and in cell lines by inducing high molecular weight oligomerization of proteins. The antitumor effect of VP is independent of its YAP inhibitor activity. Tumor hypoxia contributes partly to antitumor effect of VP by impairing clearance of VP-induced high molecular weight aggregates.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Colon Epithelial Cell

DISEASE(S): Colon Cancer

SUBMITTER: Sadeesh Ramakrishnan  

LAB HEAD: Yatrik M. Shah

PROVIDER: PXD002793 | Pride | 2015-10-14

REPOSITORIES: Pride