Hb Oxidation in stored RBCs and Vesicles

ABSTRACT: We used a state of the art proteomics workflow, based upon nano-UPLC-MS\MS and advanced database searching to identify oxidative modifications to functional residues of hemoglobin subunit beta . Progressive accumulation of oxidized residues in stored erythrocytes and selective removal in vesicles was observed, further substantiating the hypothesis about vesiculation as a self-protecting mechanism in aging erthrocytes.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Erythrocyte, Blood

DISEASE(S): Disease Free

SUBMITTER: Matthew Wither  

LAB HEAD: Angelo D'Alessandro

PROVIDER: PXD002798 | Pride | 2015-10-05

REPOSITORIES: Pride