Protein Turnover Rates in Normal and Hypertrophy Mouse Hearts
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Heart, Cardiocyte
DISEASE(S): Cardiovascular System Disease
SUBMITTER: 
Edward Lau
LAB HEAD: Peipei Ping
PROVIDER: PXD002870 | Pride | 2015-09-22
REPOSITORIES: Pride
Publications
A large dataset of protein dynamics in the mammalian heart proteome.
Lau Edward E Cao Quan Q Ng Dominic C M DC Bleakley Brian J BJ Dincer T Umut TU Bot Brian M BM Wang Ding D Liem David A DA Lam Maggie P Y MP Ge Junbo J Ping Peipei P
Scientific data 20160315
Protein stability is a major regulatory principle of protein function and cellular homeostasis. Despite limited understanding on mechanisms, disruption of protein turnover is widely implicated in diverse pathologies from heart failure to neurodegenerations. Information on global protein dynamics therefore has the potential to expand the depth and scope of disease phenotyping and therapeutic strategies. Using an integrated platform of metabolic labeling, high-resolution mass spectrometry and comp ...[more]
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