Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Epithelial Cell, Colon
SUBMITTER: Spiro Garbis
LAB HEAD: Spiros D. Garbis
PROVIDER: PXD002886 | Pride | 2016-03-15
REPOSITORIES: Pride
Giannogonas Panagiotis P Apostolou Athanasia A Manousopoulou Antigoni A Theocharis Stamatis S Macari Sofia A SA Psarras Stelios S Garbis Spiros D SD Pothoulakis Charalabos C Karalis Katia P KP
Scientific reports 20160318
In inflammatory bowel disease (IBD), compromised restitution of the epithelial barrier contributes to disease severity. Owing to the complexity in the pathogenesis of IBD, a variety of factors have been implicated in its progress. In this study, we report a functional interaction between macroautophagy and Corticotropin Releasing Hormone (Crh) in the gut. For this purpose we used DSS colitis model on Crh -/- or wild-type (wt) with pharmacological inhibition of autophagy. We uncovered sustained b ...[more]